Regulation of Connexin43 Oligomerization is Saturable

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Connexin43 Hemichannel-Mediated Regulation of Connexin43

BACKGROUND Many signaling molecules and pathways that regulate gap junctions (GJs) protein expression and function are, in fact, also controlled by GJs. We, therefore, speculated an existence of the GJ channel-mediated self-regulation of GJs. Using a cell culture model in which nonjunctional connexin43 (Cx43) hemichannels were activated by cadmium (Cd(2+)), we tested this hypothesis. PRINCIPA...

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ژورنال

عنوان ژورنال: Cell Communication & Adhesion

سال: 2005

ISSN: 1541-9061,1543-5180

DOI: 10.1080/15419060500511875